P800SO3-PEG: a renal clearable bone-targeted fluorophore for theranostic imaging.

ABSTRACT:

Background

Due to the deep tissue penetration and reduced scattering, NIR-II fluorescence imaging is advantageous over conventional visible and NIR-I fluorescence imaging for the detection of bone growth, metabolism, metastasis, and other bone-related diseases.

Methods

Bone-targeted heptamethine cyanine fluorophores were synthesized by substituting the meso-carbon with a sulfur atom, resulting in a bathochromic shift and increased fluorescence intensity. The physicochemical, optical, and thermal stability of newly synthesized bone-targeted NIR fluorophores was performed in aqueous solvents. Calcium binding, bone-specific targeting, biodistribution, pharmacokinetics, and 2D and 3D NIR imaging were performed in animal models.

Results

The newly synthesized S-substituted

SUBMITTER: Wang H 

PROVIDER: S-EPMC9526902 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature