Melanoma stem cells promote metastasis via exosomal miR-1268a inactivation of autophagy.

ABSTRACT:

Background

Metastatic melanoma has a high mortality rate and poor survival. This is associated with efficient metastatic colonization, but the underlying mechanisms remain elusive. Communication between cancer stem cells (CSCs) and cancer cells plays an important role in metastatic dissemination. Whether cancer stem cells can alter the metastatic properties of non-CSC cells; and whether exosomal crosstalk can mediate such interaction, have not been demonstrated in melanoma prior to this report.

Results

The results revealed that exosomes secreted by highly metastatic melanoma CSCs (OL-SCs) promoted the invasiveness of the low metastatic melanoma cells (OL) and accelerated metastatic progression. miR-1268a was up-regulated in cells and exosomes of OL-SCs. Moreover, OL-SCs-deri

SUBMITTER: Li X 

PROVIDER: S-EPMC9526915 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature