YAP1 protects against septic liver injury via ferroptosis resistance.

ABSTRACT:

Background

The liver plays crucial roles in sepsis and is one of the major targets for sepsis-related injuries. Ferroptosis, a newly emerged form of lytic cell death, has been implicated in sepsis related organ failure. Yes-associated protein1 (YAP1), a key regulator of the Hippo signaling pathway, may be involved in ferroptosis development. This study aimed to elucidate the role of YAP1 in septic liver injury through regulating ferroptosis, especially ferritinophagy-mediated ferroptosis.

Results

Cecal ligation and puncture (CLP) models were constructed in control (Yap1^flfl) and liver-conditional knockout mice (Yap1^fl/fl Alb-Cre) to induce septic liver injury, while LO2 cells with or without YAP1 overexpression/deletion were stimulated by lipopolysaccha

SUBMITTER: Wang J 

PROVIDER: S-EPMC9526934 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature