Quantitative measures of the vascular and neural components of the retina in adult individuals with congenital and untreated growth hormone deficiency.

ABSTRACT:

Background

The somatotrophic axis, including hypothalamic growth hormone (GH)-releasing hormone (GHRH), pituitary GH and circulating IGF-I, is critical for body size. However, the local production of GH/IGF-I (and IGF-II) and other peptides is relevant for other body functions, such as vascular, brain, and retinal function. The consequences of GH deficiency (GHD) on the retinal structure are still unclear, possibly reflecting the heterogeneity of patients and the different types of assessment in previous publications. Our purpose was to assess quantitative measures of the vascular and neural components of the retina in subjects with severe congenital isolated GHD (IGHD).

Methods

A cross-sectional study was carried out in 25 adult IGHD subjects and 25 age- and gender-matched

SUBMITTER: Menezes NV 

PROVIDER: S-EPMC9526970 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature