Obesity-Associated Neuropathy: Recent Preclinical Studies and Proposed Mechanisms.

ABSTRACT: Significance: The prevalence of metabolic syndrome (MetS) and associated obesity has increased in recent years, affecting millions worldwide. One of the most common complications of obesity is damage to the peripheral nerve system, referred to as neuropathy. The lack of disease-modifying therapy for this complication is largely due to a poor understanding of the complex neurobiology underlying neuropathy. Recent preclinical studies suggest that in addition to glucotoxic events, other mechanisms, including lipid signaling, microbiome, or inflammation, may be viable targets to prevent nerve damage and neuropathic pain in obesity. Recent Advances: Clinical and preclinical studies using diet-induced obesity rodent models have identified novel interventions that impr

SUBMITTER: Bonomo R 

PROVIDER: S-EPMC9527047 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature