Exposing the Two Contrasting Faces of STAT2 in Inflammation.

ABSTRACT: Inflammation is a natural immune defense mechanism of the body's response to injury, infection, and other damaging triggers. Uncontrolled inflammation may become chronic and contribute to a range of chronic inflammatory diseases. Signal transducer and activator of transcription 2 (STAT2) is an essential transcription factor exclusive to type I and type III interferon (IFN) signaling pathways. Both pathways are involved in multiple biological processes, including powering the immune system as a means of controlling infection that must be tightly regulated to offset the development of persistent inflammation. While studies depict STAT2 as protective in promoting host defense, new evidence is accumulating that exposes the deleterious side of STAT2 when inappropriately regulated, thus promptin

SUBMITTER: Duodu P 

PROVIDER: S-EPMC9527059 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature