Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 years.

ABSTRACT: Clonal hematopoiesis, especially that of indeterminate potential (CHIP), has been associated with age-related diseases, such as those contributing to a more severe COVID-19. Four studies have attempted to associate CHIP with COVID-19 severity without conclusive findings. In the present work, we explore the association between CHIP and COVID-19 mortality. Genomic DNA extracted from peripheral blood of COVID-19 patients (n = 241 deceased, n = 239 survivors) was sequenced with the Myeloid Solutions™ panel of SOPHiA Genetics. The association between clonality and age and clonality and mortality was studied using logistic regression models adjusted for sex, ethnicity, and comorbidities. The association with mortality was performed with patients stratified into four groups of age according to th

SUBMITTER: Del Pozo-Valero M 

PROVIDER: S-EPMC9527133 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature