Determination of soluble angiotensin-converting enzyme 2 in saliva samples and its association with nicotine.

ABSTRACT:

Introduction

The Angiotensin-Converting Enzyme 2 (ACE2) is the main receptor of the SARS-CoV-2. There is contradictory evidence on how the exposure to nicotine may module the concentration of soluble ACE2 (sACE2). The aim of this study was to assess the association between nicotine and sACE2 concentrations in saliva samples.

Methods

Pooled analysis performed with data retrieved from two studies (n = 634 and n = 302). Geometric mean (GM) concentrations of sACE2, both total and relative to the total amount of protein in the sample, were compared according to sociodemographic variables and variables associated to nicotine. Multivariable linear regression models were fitted to explore the associations of sACE2 with nicotine adjusting for sex, age and body mass index. Spearman's

SUBMITTER: Bru S 

PROVIDER: S-EPMC9527194 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature