Glutamate and GABA_A receptor crosstalk mediates homeostatic regulation of neuronal excitation in the mammalian brain.

ABSTRACT: Maintaining a proper balance between the glutamate receptor-mediated neuronal excitation and the A type of GABA receptor (GABA_AR) mediated inhibition is essential for brain functioning; and its imbalance contributes to the pathogenesis of many brain disorders including neurodegenerative diseases and mental illnesses. Here we identify a novel glutamate-GABA_AR interaction mediated by a direct glutamate binding of the GABA_AR. In HEK293 cells overexpressing recombinant GABA_ARs, glutamate and its analog ligands, while producing no current on their own, potentiate GABA-evoked currents. This potentiation is mediated by a direct binding at a novel glutamate binding pocket located at the α⁺/β^- subunit interface of the GABA_A

SUBMITTER: Wen Y 

PROVIDER: S-EPMC9527238 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature