The contribution of the ¹H-MRS lipid signal to cervical cancer prognosis: a preliminary study.

ABSTRACT:

Background

The aim of this study was to investigate the role of the lipid peak derived from ¹H magnetic resonance (MR) spectroscopy in assessing cervical cancer prognosis, particularly in assessing response to neoadjuvant chemotherapy (NACT) of locally advanced cervical cancer (LACC).

Methods

We enrolled 17 patients with histologically proven cervical cancer who underwent 3-T MR imaging at baseline. In addition to conventional imaging sequences for pelvic assessment, the protocol included a single-voxel point-resolved spectroscopy (PRESS) sequence, with repetition time of 1,500 ms and echo times of 28 and 144 ms. Spectra were analysed using the LCModel fitting routine, thus extracting multiple metabolites, including lipids (Lip) and total choline (tCho). Patients

SUBMITTER: Dolciami M 

PROVIDER: S-EPMC9527268 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature