One of the active ingredients in Paeoniae Radix Alba functions as JAK1 inhibitor in rheumatoid arthritis.

ABSTRACT: Objective: We aimed to explore and verify the mechanism underlying the action of the active ingredients of Paeoniae Radix Alba (PRA) in the treatment of rheumatoid arthritis (RA). Methods: The protein targets of PRA's six active ingredients and RA were identified. Then, the intersection of the two groups was studied. The drug-target network was constructed, visualized, and analyzed by Cytoscape software. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment were performed to analyze these genes. Furthermore, we validated our predictions of the potential targets through a docking study. Finally, the anti-inflammatory effect of Palbinone (PB), one of the active ingredients of PRA, was tested by conducting in vitro and in vivo stud

SUBMITTER: Xiao L 

PROVIDER: S-EPMC9527307 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature