The resealing factor S100A11 interacts with annexins and extended synaptotagmin-1 in the course of plasma membrane wound repair.

ABSTRACT: After damage, cells repair their plasma membrane in an active process that is driven by Ca²⁺ entering through the wound. This triggers a range of Ca²⁺-regulated events such as the translocation of different Ca²⁺-binding proteins to the wound site which likely function in the repair process. The translocated proteins include Ca²⁺/phospholipid binding proteins of the annexin (ANX) family and S100A11, an EF hand-type Ca²⁺-binding protein which can interact with ANX. The molecular mechanism by which S100A11 mediates PM wound repair remains poorly understood although it likely involves interactions with ANX. Here, using S100A11 knockout endothelial cells and expression of S100A11 mutants, we show that endothelial S100A11 is essential for ef

SUBMITTER: Ashraf APK 

PROVIDER: S-EPMC9527316 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature