Aggregation behavior of nanoparticles: Revisiting the phase diagram of colloids.

ABSTRACT: Surface functionalization of metal nanoparticles (NPs), e.g., using peptides and proteins, has recently attracted a considerable attention in the field of design of therapeutics and diagnostics. The possibility of diverse functionalization allows them to selectively interact with proteins, while the metal core ensures solubility, making them tunable therapeutic agents against diseases due to mis-folding or aggregation. On the other hand, their action is limited by possible self-aggregation, which could be, however, prevented based on the full understanding of their phase diagram as a function of the environmental variables (temperature, ionic strength of the solution, concentration) and intrinsic characteristics (size, charge, amount, and type of functional groups). A common modeling strat

SUBMITTER: Bini M 

PROVIDER: S-EPMC9527328 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature