Regulatory pattern of abnormal promoter CpG island methylation in the glioblastoma multiforme classification.

ABSTRACT: Glioblastoma (GBM) is characterized by extensive genetic and phenotypic heterogeneity. However, it remains unexplored primarily how CpG island methylation abnormalities in promoter mediate glioblastoma typing. First, we presented a multi-omics scale map between glioblastoma sample clusters constructed based on promoter CpG island (PCGI) methylation-driven genes, using datasets including methylation profiles, expression profiles, and single-cell sequencing data from multiple highly annotated public clinical cohorts. Second, we identified differences in the tumor microenvironment between the two glioblastoma sample clusters and resolved key signaling pathways between cell clusters at the single-cell level based on comprehensive comparative analyses to investigate the reasons for survival dif

SUBMITTER: Wang R 

PROVIDER: S-EPMC9527345 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature