Progesterone supplementation in natural cycles improves live birth rates after embryo transfer of frozen-thawed embryos-a randomized controlled trial.

ABSTRACT:

Study question

Does supplementation with vaginal tablets of progesterone after frozen-thawed embryo transfer in natural cycles improve the live birth rate?

Summary answer

Supplementation with vaginal tablets of progesterone after frozen-thawed embryo transfer in natural cycles significantly improves the number of live births.

What is known already

Progesterone supplementation during luteal phase and early pregnancy may improve the number of live births after frozen-thawed embryo transfer. However, due to the limited number of previous studies, being mainly retrospective, evidence is still limited.

Study design, size, duration

This is a prospective randomized controlled trial, performed at two university clinics. In total, 500 subjects were randomized with a 1:1

SUBMITTER: Wanggren K 

PROVIDER: S-EPMC9527461 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature