Markers of ovarian reserve are associated with reproductive age acceleration in granulosa cells from IVF patients.

ABSTRACT:

Study question

Is reproductive aging in granulosa cells associated with markers of ovarian reserve?

Summary answer

Age acceleration was associated with anti-Mullerian hormone (AMH) levels, antral follicle count (AFC), oocyte yield and maturity, and the number of successfully fertilized embryos.

What is known already

The rate of reproductive aging varies among women of the same age. DNA methylation can be used to predict epigenetic age in a variety of tissues.

Study design, size, duration

This was a cross-sectional study of 70 women at the time of oocyte retrieval.

Participants/materials, setting, methods

The 70 participants were recruited for this study at an academic medical center and they provided follicular fluid samples at the time of oocyte retriev

SUBMITTER: Knight AK 

PROVIDER: S-EPMC9527469 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature