Tumor-related molecular determinants of neurocognitive deficits in patients with diffuse glioma.

ABSTRACT:

Background

Cognitive impairment is a common and debilitating symptom in patients with diffuse glioma, and is the result of multiple factors. We hypothesized that molecular tumor characteristics influence neurocognitive functioning (NCF), and aimed to identify tumor-related markers of NCF in diffuse glioma patients.

Methods

We examined the relation between cognitive performance (executive function, memory, and psychomotor speed) and intratumoral expression levels of molecular markers in treatment-naive patients with diffuse glioma. We performed a single-center study in a consecutive cohort, through a two-step design: (1) hypothesis-free differential expression and gene set enrichment analysis to identify candidate oncogenetic markers for cognitive impairment. Nineteen molecul

SUBMITTER: van Kessel E 

PROVIDER: S-EPMC9527514 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature