Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice.

ABSTRACT:

Background

Calcium dysregulation has been proposed to play a causative role in the development of Alzheimer's disease pathology. Pregabalin is a compound already approved for human use, marketed as the prescription drug Lyrica. It binds the α2-δ subunit of P/Q-type voltagegated calcium channels, lowering calcium influx and providing effective treatment for epilepsy and neuropathic pain.

Objective

We hypothesize that increased resting calcium in neuronal processes near amyloid plaques plays a role in the development of neuritic dystrophies and further progression of amyloid pathology.

Methods

5XFAD mice were treated orally for 12 weeks with pregabalin, then immunoblotting and immunofluorescent imaging were used to quantify neuritic dystrophy and amyloid deposition in p

SUBMITTER: Sadleir KR 

PROVIDER: S-EPMC9527523 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature