ERCC5, HES6 and RORA are potential diagnostic markers of coronary artery disease.

ABSTRACT: The mortality rate of patients with coronary artery disease (CAD) increases year by year, and the age of onset is decreasing, primarily because of the lack of an efficient and convenient diagnostic method for CAD. In the present study, we aimed to detect CAD-correlated biomarkers and the regulatory pathways involved through weighted co-expression network analysis. The microarray data originated from 93 CAD patients and 48 controls within the Gene Expression Omnibus (GEO) database. The gene network was implemented by weighted gene co-expression network analysis, and the genes were observed to fall into a range of modules. We took the intersection of genes in the modules most correlated with CAD with the differentially expressed genes of CAD, which were identified by applying the limma packa

SUBMITTER: Bai Z 

PROVIDER: S-EPMC9527589 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature