Association Between Inflammatory Bowel Disease and Dementia: A Longitudinal Cohort Study.

ABSTRACT:

Background

The association between inflammatory bowel disease (IBD) and dementia remains uncertain. We aim to investigate whether IBD is associated with higher dementia risk.

Methods

Using multivariable Cox regression models, we analyzed the onset of all-cause dementia among 497,775 participants, including 5778 IBD patients in the UK Biobank as primary analysis. In secondary analysis, we further examined the difference in brain structure and cognitive function changes between IBD and non-IBD individuals. The diagnosis of IBD and dementia was confirmed with combination of primary care data, hospital inpatient data, death registry, and self-report data. Brain structure was measured by brain MRI as anatomic and tissue-specific volumes; cognitive function was tested in terms of

SUBMITTER: Sun Y 

PROVIDER: S-EPMC9527613 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature