Emulating the GRADE trial using real world data: retrospective comparative effectiveness study.

ABSTRACT:

Objective

To emulate the GRADE (Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study) trial using real world data before its publication. GRADE directly compared second line glucose lowering drugs for their ability to lower glycated hemoglobin A_1c (HbA_1c).

Design

Observational study.

Setting

OptumLabs® Data Warehouse (OLDW), a nationwide claims database in the US, 25 January 2010 to 30 June 2019.

Participants

Adults with type 2 diabetes and HbA_1c 6.8-8.5% while using metformin monotherapy, identified according to the GRADE trial specifications, who also used glimepiride, liraglutide, sitagliptin, or insulin glargine.

Main outcome measures

The primary outcome was time to HbA_1c ≥7.0%. Seco

SUBMITTER: Deng Y 

PROVIDER: S-EPMC9527635 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature