Anterior default mode network and posterior insular connectivity is predictive of depressive symptom reduction following serial ketamine infusion.

ABSTRACT:

Background

Ketamine is a rapidly-acting antidepressant treatment with robust response rates. Previous studies have reported that serial ketamine therapy modulates resting state functional connectivity in several large-scale networks, though it remains unknown whether variations in brain structure, function, and connectivity impact subsequent treatment success. We used a data-driven approach to determine whether pretreatment multimodal neuroimaging measures predict changes along symptom dimensions of depression following serial ketamine infusion.

Methods

Patients with depression (n = 60) received structural, resting state functional, and diffusion MRI scans before treatment. Depressive symptoms were assessed using the 17-item Hamilton Depression Rating Scale (HDRS-17),

SUBMITTER: Wade BSC 

PROVIDER: S-EPMC9527672 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature