Interaction of night shift work with polymorphism in melatonin receptor 1B gene on incident stroke.

ABSTRACT:

Objectives

The aim of this study was to investigate whether melatonin receptor type 1B (MTNR1B) rs10830963 polymorphism interacts with night shift work on the risk of incident stroke.

Methods

This study included individuals free of stroke at baseline from the UK Biobank. Night-shift work was assessed by the self-reported questions. MTNR1B rs10830963 was directly genotyped (CC, GC, and GG). Incident stroke was ascertained through hospital records and death registries. Cox proportional hazards models were employed to examine the associations of night shift work and MTNR1B rs10830963 with the risk of incident stroke.

Results

A total of 242 194 participants were finally included (mean age: 52.95 years; 51.63% women). Over 12-year follow-up, 3287 incident stroke events occ

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9527780 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature