Evolution of the cardiac dyad.

ABSTRACT: Cardiac dyads are the site of communication between the sarcoplasmic reticulum (SR) and infoldings of the sarcolemma called transverse-tubules (TT). During heart excitation-contraction coupling, Ca²⁺-influx through L-type Ca²⁺ channels in the TT is amplified by release of Ca²⁺-from the SR via type 2 ryanodine receptors, activating the contractile apparatus. Key proteins involved in cardiac dyad function are bridging integrator 1 (BIN1), junctophilin 2 and caveolin 3. The work presented here aims to reconstruct the evolutionary history of the cardiac dyad, by surveying the scientific literature for ultrastructural evidence of these junctions across all animal taxa; phylogenetically reconstructing the evolutionary history of BIN1; and by comparing peptide mot

SUBMITTER: Mackrill JJ 

PROVIDER: S-EPMC9527923 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature