Sarcomere maturation: function acquisition, molecular mechanism, and interplay with other organelles.

ABSTRACT: During postnatal cardiac development, cardiomyocytes mature and turn into adult ones. Hence, all cellular properties, including morphology, structure, physiology and metabolism, are changed. One of the most important aspects is the contractile apparatus, of which the minimum unit is known as a sarcomere. Sarcomere maturation is evident by enhanced sarcomere alignment, ultrastructural organization and myofibrillar isoform switching. Any maturation process failure may result in cardiomyopathy. Sarcomere function is intricately related to other organelles, and the growing evidence suggests reciprocal regulation of sarcomere and mitochondria on their maturation. Herein, we summarize the molecular mechanism that regulates sarcomere maturation and the interplay between sarcomere and other organe

SUBMITTER: Ahmed RE 

PROVIDER: S-EPMC9527934 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature