Acute Implantation of Aligned Hydrogel Tubes Supports Delayed Spinal Progenitor Implantation.

ABSTRACT: An important role of neural stem cell transplantation is repopulating neural and glial cells that actively promote repair following spinal cord injury (SCI). However, stem cell survival after transplantation is severely hampered by the inflammatory environment that arises after SCI. Biomaterials have a demonstrated history of managing post-SCI inflammation and can serve as a vehicle for stem cell delivery. In this study, we utilize macroporous polyethylene glycol (PEG) tubes, which were previously found to modulate the post-SCI microenvironment, to serve as a viable, soft substrate for injecting mouse embryonic day 14 (E14) spinal progenitors 2 weeks after tube implantation into a mouse SCI model. At 2 weeks after transplantation (4 weeks after injury), 4.3% of transplanted E14 spinal prog

SUBMITTER: Ciciriello AJ 

PROVIDER: S-EPMC9527948 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature