Arterial Stiffness and Chronic Kidney Disease Progression in Children.

ABSTRACT:

Background and objectives

CKD has been linked to increased arterial stiffness in adults, but data in children with CKD remain conflicting. We aimed to investigate the longitudinal dynamics and determinants of pulse wave velocity in children with CKD and its association with CKD progression.

Design, setting, participants, & measurements

We performed an analysis of the Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) study, which prospectively followed children aged 6-17 years with CKD stages 3-5. Follow-up was censored at the time of KRT initiation. Two separate analyses were performed: with absolute pulse wave velocity (primary outcome) and with pulse wave velocity standardized to height (z score; restricted to participants ≤17 years) as a sensi

SUBMITTER: Azukaitis K 

PROVIDER: S-EPMC9528270 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature