Apolipoprotein L1 Genotypes and the Association of Urinary Potassium Excretion with CKD Progression.

ABSTRACT:

Background and objectives

Progressive CKD in Black individuals is strongly associated with polymorphisms in the APOL1 gene, but it is unknown whether dietary risk factors for CKD progression vary in high- versus low-risk APOL1 genotypes. We investigated if APOL1 genotypes modify associations of dietary potassium and sodium with CKD progression and death.

Design, setting, participants, & measurements

We analyzed 1399 self-identified Black participants enrolled in the Chronic Renal Insufficiency Cohort from April 2003 to September 2008. Exposures were calibrated 24-hour urine potassium and sodium excretion. The primary outcome was CKD progression defined as the time to 50% decline in eGFR or kidney failure. The secondary outcome was CKD progression or deat

SUBMITTER: Ilori TO 

PROVIDER: S-EPMC9528272 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature