Markers of Kidney Tubular Secretion and Risk of Adverse Events in SPRINT Participants with CKD.

ABSTRACT:

Background

Kidney tubular secretion is an essential mechanism for clearing many common antihypertensive drugs and other metabolites and toxins. It is unknown whether novel measures of tubular secretion are associated with adverse events (AEs) during hypertension treatment.

Methods

Among 2089 SPRINT (Systolic Blood Pressure Intervention Trial) participants with baseline eGFR <60 ml/min per 1.73 m², we created a summary secretion score by averaging across the standardized spot urine-to-plasma ratios of ten novel endogenous tubular secretion measures, with lower urine-to-plasma ratios reflecting worse tubular secretion. Multivariable Cox proportional hazards models were used to evaluate associations between the secretion score and risk of a composite of prespecified

SUBMITTER: Bullen AL 

PROVIDER: S-EPMC9528325 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature