Blocking CCL8-CCR8-Mediated Early Allograft Inflammation Improves Kidney Transplant Function.

ABSTRACT:

Background

In kidney transplantation, early allograft inflammation impairs long-term allograft function. However, precise mediators of early kidney allograft inflammation are unclear, making it challenging to design therapeutic interventions.

Methods

We used an allogeneic murine kidney transplant model in which CD45.2 BALB/c kidneys were transplanted to CD45.1 C57BL/6 recipients.

Results

Donor kidney resident macrophages within the allograft expanded rapidly in the first 3 days. During this period, they were also induced to express a high level of Ccl8, which, in turn, promoted recipient monocyte graft infiltration, their differentiation to resident macrophages, and subsequent expression of Ccl8. Enhanced graft infiltration of recipient CCR8⁺

SUBMITTER: Dangi A 

PROVIDER: S-EPMC9528333 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature