Fontan Geometry and Hemodynamics Are Associated With Quality of Life in Adolescents and Young Adults.

ABSTRACT:

Background

Despite favorable short-term outcomes, Fontan palliation is associated with comorbidities and diminished quality of life (QOL) in the years after completion. We hypothesized that poor Fontan hemodynamics and ventricular function are associated with worse QOL.

Methods

This was a single-center study of Fontan survivors aged more than 12 years. Subjects completed a cardiac magnetic resonance scan and QOL questionnaire. Cardiac magnetic resonance-derived variables included Fontan geometry, and hemodynamics. Computational fluid dynamics simulations quantified power loss, pressure drop, and total cavopulmonary connection resistance across the Fontan. Quality of life was assessed by completion of the Pediatric Quality of Life Inventory. Longitudinal and cross-sectional c

SUBMITTER: Mercer-Rosa L 

PROVIDER: S-EPMC9528566 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature