Peer Reviewed Evaluation of Registered End-Points of Randomised Trials (the PRE-REPORT study): a stepped wedge, cluster-randomised trial.

ABSTRACT:

Objective

To test whether providing relevant clinical trial registry information to peer reviewers evaluating trial manuscripts decreases discrepancies between registered and published trial outcomes.

Design

Stepped wedge, cluster-randomised trial, with clusters comprised of eligible manuscripts submitted to each participating journal between 1 November 2018 and 31 October 2019.

Setting

Thirteen medical journals.

Participants

Manuscripts were eligible for inclusion if they were submitted to a participating journal during the study period, presented results from the primary analysis of a clinical trial, and were peer reviewed.

Interventions

During the control phase, there were no changes to pre-existing peer review practices. After journals crossed over i

SUBMITTER: Jones CW 

PROVIDER: S-EPMC9528603 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature