Differences in the stemness characteristics and molecular markers of distinct human oral tissue neural crest-derived multilineage cells.

ABSTRACT:

Objectives

Although multilineage cells derived from oral tissues, especially the dental pulp, apical papilla, periodontal ligament, and oral mucosa, have neural crest-derived stem cell (NCSC)-like properties, the differences in the characteristics of these progenitor cell compartments remain unknown. The current study aimed to elucidate these differences.

Material and methods

Sphere-forming apical papilla-derived cells (APDCs), periodontal ligament-derived cells (PDLDCs), and oral mucosa stroma-derived cells (OMSDCs) from the same individuals were isolated from impacted developing teeth. All sphere-forming cells were characterized through biological analyses of stem cells.

Results

All sphere-forming cells expressed neural crest-related markers. The expression of certa

SUBMITTER: Abe S 

PROVIDER: S-EPMC9528771 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature