A randomized controlled pilot study of intranasal lidocaine in acute management of paediatric migraine and migraine-like headache.

ABSTRACT:

Objectives

This study was aimed to determine the sample size required to conduct an efficacy randomized controlled trial (RCT) to evaluate superiority of intranasal (IN) lidocaine to placebo as an analgesic option for children presenting to the paediatric emergency department (PED) with migraine or posttraumatic headache with migraine features and to evaluate study protocol feasibility.

Study design

This study is a double-blind RCT of children aged 7 to 16 years at a single-centre PED. Thirty-two participants were randomized to receive either IN 2% lidocaine or 0.9% sodium chloride. The primary outcome measure was the proportion of subjects with a Verbal Numeric Rating Scale pain score of <4 at 30 and 60 minutes post-IN therapy. Primary outcome data were analyzed using a tes

SUBMITTER: Maki K 

PROVIDER: S-EPMC9528783 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature