Dataset Information

Risks of Severe COVID-19 Outcomes Among Patients With Diabetic Polyneuropathy in the United States.

ABSTRACT:

Context

Diabetic neuropathy (DN) affects more than 50% of diabetic patients who are also likely to have compromised immune system and respiratory function, both of which can make them susceptible to the SARS-CoV-2 virus.

Objective

To assess the risk of severe COVID-19 illness among adults with DN, compared with those with no DN and those with no diabetes.

Setting

The analysis utilized electronic health records from 55 US health care organizations in the TriNetX research database.

Design

A retrospective cohort study.

Participants

The analysis included 882 650 adults diagnosed with COVID-19 in January 2020 to June 2021, including 16 641 with DN, 81 329 with diabetes with no neuropathy, and 784 680 with no diabetes.

Outcome measures

The presence of health care utilization (admissions to emergency department, hospital, intensive care unit), 30-day mortality, clinical presentation (cough, fever, hypoxemia, dyspnea, or acute respiratory distress syndrome), and diagnostic test results after being infected affected by COVID-19.

Results

The DN cohort was 1.19 to 2.47 times more likely than the non-DN cohorts to utilize care resources, receive critical care, and have higher 30-day mortality rates. Patients with DN also showed increased risk (1.13-2.18 times) of severe symptoms, such as hypoxemia, dyspnea, and acute respiratory distress syndrome.

Conclusions

Patients with DN had a significantly greater risk of developing severe COVID-19-related complications than those with no DN. It is critical for the public health community to continue preventive measures, such as social distancing, wearing masks, and vaccination, to reduce infection rates, particularly in higher risk groups, such as those with DN.

SUBMITTER: Tuan WJ

PROVIDER: S-EPMC9528940 | biostudies-literature | 2022 Nov-Dec 01

REPOSITORIES: biostudies-literature

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Publications

Risks of Severe COVID-19 Outcomes Among Patients With Diabetic Polyneuropathy in the United States.

Tuan Wen-Jan WJ Lennon Robert P RP Zhang Alice A Macherla Ajay A Zgierska Aleksandra E AE

Journal of public health management and practice : JPHMP 20220827 6

<h4>Context</h4>Diabetic neuropathy (DN) affects more than 50% of diabetic patients who are also likely to have compromised immune system and respiratory function, both of which can make them susceptible to the SARS-CoV-2 virus.<h4>Objective</h4>To assess the risk of severe COVID-19 illness among adults with DN, compared with those with no DN and those with no diabetes.<h4>Setting</h4>The analysis utilized electronic health records from 55 US health care organizations in the TriNetX research dat ...[more]

PMID: 36037512

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Project description:BackgroundStudies have shown worse outcomes in patients with comorbid ischemic stroke (IS) and coronavirus disease 2019 (COVID-19), but have had small sample sizes.MethodsWe retrospectively identified patients in the Vizient Clinical Data Base® with IS as a discharge diagnosis. The study outcomes were in-hospital death and favorable discharge (home or acute rehabilitation). In the primary analysis, we compared IS patients with laboratory-confirmed COVID-19 (IS-COVID) discharged April 1-July 31, 2020 to pre-COVID IS patients discharged in 2019 (IS controls). In a secondary analysis, we compared a matched cohort of IS-COVID patients to patients within the IS controls who had pneumonia (IS-PNA), created with inverse-probability-weighting (IPW).ResultsIn the primary analysis, we included 166,586 IS controls and 2086 IS-COVID from 312 hospitals in 46 states. Compared to IS controls, IS-COVID were less likely to have hypertension, dyslipidemia, or be smokers, but more likely to be male, younger, have diabetes, obesity, acute renal failure, acute coronary syndrome, venous thromboembolism, intubation, and comorbid intracerebral or subarachnoid hemorrhage (all p<0.05). Black and Hispanic patients accounted for 21.7% and 7.4% of IS controls, respectively, but 33.7% and 18.5% of IS-COVID (p<0.001). IS-COVID, versus IS controls, were less likely to receive alteplase (1.8% vs 5.6%, p<0.001), mechanical thrombectomy (4.4% vs. 6.7%, p<0.001), to have favorable discharge (33.9% vs. 66.4%, p<0.001), but more likely to die (30.4% vs. 6.5%, p<0.001). In the matched cohort of patients with IS-COVID and IS-PNA, IS-COVID had a higher risk of death (IPW-weighted OR 1.56, 95% CI 1.33-1.82) and lower odds of favorable discharge (IPW-weighted OR 0.63, 95% CI 0.54-0.73).ConclusionsIschemic stroke patients with COVID-19 are more likely to be male, younger, and Black or Hispanic, with significant increases in morbidity and mortality compared to both ischemic stroke controls from 2019 and to patients with ischemic stroke and pneumonia.

Dataset Information

Risks of Severe COVID-19 Outcomes Among Patients With Diabetic Polyneuropathy in the United States.

Context

Objective

Setting

Design

Participants

Outcome measures

Results

Conclusions

Publications

Risks of Severe COVID-19 Outcomes Among Patients With Diabetic Polyneuropathy in the United States.

Similar Datasets

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