Single-cell multi-omics of human preimplantation embryos shows susceptibility to glucocorticoids.

ABSTRACT: The preconceptual, intrauterine, and early life environments can have a profound and long-lasting impact on the developmental trajectories and health outcomes of the offspring. Given the relatively low success rates of assisted reproductive technologies (ART; ∼25%), additives and adjuvants, such as glucocorticoids, are used to improve the success rate. Considering the dynamic developmental events that occur during this window, these exposures may alter blastocyst formation at a molecular level, and as such, affect not only the viability of the embryo and the ability of the blastocyst to implant, but also the developmental trajectory of the first three cell lineages, ultimately influencing the physiology of the embryo. In this study, we present a comprehensive single-cell transcriptome, met

SUBMITTER: Zhao C 

PROVIDER: S-EPMC9528977 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature