Impact of CYP3A5 Status on the Clinical and Financial Outcomes Among African American Kidney Transplant Recipients

ABSTRACT: Background. Pharmacogenetic profiling of transplant recipients demonstrates that the marked variation in the metabolism of immunosuppressive medications, particularly tacrolimus, is related to genetic variants. Patients of African ancestry are less likely to carry loss-of-function (LoF) variants in the CYP3A5 gene and therefore retain a rapid metabolism phenotype and higher clearance of tacrolimus. Patients with this rapid metabolism typically require higher dosing to achieve therapeutic trough concentrations. This study aims to further characterize the impact of CYP3A5 genotype on clinical outcomes and financial expenditure.

Methods.

The CYP3A5 phenotype status was identified in 438 adult kidney transplant (KTx) recipients (96% were African American) using 3 LoF alleles (CYP3A5*3

SUBMITTER: Obayemi J 

PROVIDER: S-EPMC9529042 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature