Systematic Review and Meta-Analysis of Plasma and Urine Biomarkers for CKD Outcomes.

ABSTRACT:

Background

Sensitive and specific biomarkers are needed to provide better biologic insight into the risk of incident and progressive CKD. However, studies have been limited by sample size and design heterogeneity.

Methods

In this assessment of the prognostic value of preclinical plasma and urine biomarkers for CKD outcomes, we searched Embase (Ovid), MEDLINE ALL (Ovid), and Scopus up to November 30, 2020, for studies exploring the association between baseline kidney biomarkers and CKD outcomes (incident CKD, CKD progression, or incident ESKD). We used random-effects meta-analysis.

Results

After screening 26,456 abstracts and 352 full-text articles, we included 129 studies in the meta-analysis for the most frequently studied plasma biomarkers (TNFR1, FGF23, TNFR2, KIM-

SUBMITTER: Liu C 

PROVIDER: S-EPMC9529190 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature