Targeting Cellular Senescence for Age-Related Diseases: Path to Clinical Translation.

ABSTRACT:

Summary

Beyond the palliative reach of today's medicines, medical therapies of tomorrow aim to treat the root cause of age-related diseases by targeting fundamental aging mechanisms. Pillars of aging include, among others, genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, dysregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. The unitary theory of fundamental aging processes posits that by targeting one fundamental aging process, it may be feasible to impact several or all others given its interdependence. Indeed, pathologic accumulation of senescent cells is implicated in chronic diseases and age-associated morbidities, suggesting that senescent cells are a g

SUBMITTER: Wyles SP 

PROVIDER: S-EPMC9529239 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature