Model-based evaluation of the impact of prophylactic vaccination applied to Ebola epidemics in Sierra Leone and Democratic Republic of Congo.

ABSTRACT:

Background

Protection by preventive Ebola vaccines has been demonstrated in clinical trials, but a complete picture of real-world effectiveness is lacking. Our previous study modeling the impact of preventively vaccinating healthcare workers (HCW) alone or with a proportion of the general population (GP) estimated significant reductions in incidence and mortality. The model assumed 100% vaccine efficacy, which is unlikely in the real world. We enhanced this model to account for lower vaccine efficacy and to factor in reduced infectiousness and lower case fatality rate in vaccinated individuals with breakthrough infections.

Methods

The previous model was enhanced to still permit a risk, although lower, for vaccinated individuals to become infected. The enhanced model, calibra

SUBMITTER: Potluri R 

PROVIDER: S-EPMC9529325 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature