Ontology highlight
ABSTRACT:
SUBMITTER: Becklin KL
PROVIDER: S-EPMC9529369 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Becklin Kelsie L KL Draper Garrett M GM Madden Rebecca A RA Kluesner Mitchell G MG Koga Tomoyuki T Huang Miller M Weiss William A WA Spector Logan G LG Largaespada David A DA Moriarity Branden S BS Webber Beau R BR
The CRISPR journal 20220801 4
Advances in genome and tissue engineering have spurred significant progress and opportunity for innovation in cancer modeling. Human induced pluripotent stem cells (iPSCs) are an established and powerful tool to study cellular processes in the context of disease-specific genetic backgrounds; however, their application to cancer has been limited by the resistance of many transformed cells to undergo successful reprogramming. Here, we review the status of human iPSC modeling of solid tumors in the ...[more]