Association of Pathology Markers with Somatostatin Analogue Responsiveness in Acromegaly.

ABSTRACT:

Background

Somatotroph adenomas (SAs) exhibit a variable responsiveness to somatostatin analogue (SS-a) treatment, a process that is not well understood. We investigated established and novel histological markers as predictors of SS-a responsiveness.

Methods

We retrospectively investigated pathology samples from 36 acromegalic patients that underwent transsphenoidal surgery. Clinical, hormonal, and imaging data were available in 24/36 patients, before and after SS-a treatment. Specimens were semiquantitatively analyzed with immunocytochemistry for Ki-67, KER, SSTR-2, SSTR-5, ZAC-1, E-cadherin, and AIP.

Results

Collectively, 18 (50%) adenomas were each classified as densely/sparsely granulated somatotroph adenomas (DGSAs/SGSAs), respectively. Patients that received pre

SUBMITTER: Kontogeorgos G 

PROVIDER: S-EPMC9529452 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature