Differentiating Primary Tumors for Brain Metastasis with Integrated Radiomics from Multiple Imaging Modalities.

ABSTRACT:

Objectives

To differentiate the primary site of brain metastases (BMs) is of high clinical value for the successful management of patients with BM. The purpose of this study is to investigate a combined radiomics model with computer tomography (CT) and magnetic resonance imaging (MRI) images in differentiating BMs originated from lung and breast cancer.

Methods

Pretreatment cerebral contrast enhanced CT and T1-weighted MRI images of 78 patients with 179 BMs from primary lung and breast cancer were retrospectively analyzed. Radiomic features were extracted from contoured BM lesions and selected using the Mann-Whitney U test and the least absolute shrinkage and selection operator (LASSO) logistic regression. Binary logistic regression (BLR) and support vector machine (S

SUBMITTER: Cao G 

PROVIDER: S-EPMC9529469 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature