The PDGF Family Is Associated with Activated Tumor Stroma and Poor Prognosis in Ovarian Cancer.

ABSTRACT: The initiation and progression of cancer depend on the genetic alterations inherent in cancer cells, coupled with the mutual interplay of cancer cells with the surrounding tumor stroma. The platelet-derived growth factor (PDGF) family, as a mesenchymal growth factor, was involved in tumor progression by affecting the surrounding tumor stroma in some cancer types. However, the association of the PDGF family with the ovarian cancer stroma remains elusive. In our study, we first explored the expression pattern of the PDGF family using RNA expression profiles from public databases. We found that the PDGF family was highly expressed in tumor stroma compared with the corresponding epithelial components of ovarian cancer. In particular, PDGF receptors were weakly expressed in ovarian cancer tissu

SUBMITTER: Li J 

PROVIDER: S-EPMC9529473 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature