PET imaging of hepatocellular carcinoma by targeting tumor-associated endothelium using [⁶⁸Ga]Ga-PSMA-617.

ABSTRACT:

Objective

Hepatocellular carcinoma (HCC) is a malignant tumor associated with high morbidity and mortality rates. In many non-prostate solid tumors such as HCC, prostate-specific membrane antigens (PSMA) are overexpressed in tumor-associated endothelial cells. Therefore, the aim of this study was to evaluate the performance of [⁶⁸Ga]Ga-PSMA-617 PET imaging on HCC with different animal models, including cell line-derived xenografts (CDX) and patient-derived xenografts (PDX), and to explore its mechanisms of function.

Methods

[⁶⁸Ga]Ga-PSMA-617 was prepared. The expression level of PSMA in two human hepatocellular cancer cells (HepG2 and HuH-7) was evaluated, and the cellular uptakes of [⁶⁸Ga]Ga-PSMA-617 were assayed. HepG2 and HuH-7 subcutaneou

SUBMITTER: Lu Q 

PROVIDER: S-EPMC9529836 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature