Prenatal Lipopolysaccharides Exposure Induces Transgenerational Inheritance of Hypertension.

ABSTRACT:

Background

Adverse environmental exposure during the prenatal period can lead to diseases in the offspring, including hypertension. Whether or not the hypertensive phenotype can be transgenerationally transmitted is not known.

Methods

Pregnant Sprague Dawley rats were intraperitoneally injected with lipopolysaccharide (LPS) on gestation days 6, 8, 10, and 12 to generate the prenatal LPS exposure model. Blood pressure was monitored by both telemetry and tail-cuff method. RNA sequencing was performed to analyze transcriptome alteration in the kidney of the third generation. Tempol and spironolactone were used to test the potential preventative and therapeutic effect of targeting reactive oxygen species and mineralocorticoid receptor signaling, respectively. Molecular biologica

SUBMITTER: Cao N 

PROVIDER: S-EPMC9529859 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature