Peripheral level of CD33 and Alzheimer's disease: a bidirectional two-sample Mendelian randomization study.

ABSTRACT: Increased expression of CD33 in the brain has been suggested to be associated with increased amyloid plaque burden, while the peripheral level of CD33 in Alzheimer's disease (AD) patients and its role in AD remain unclear. The current study aimed to systematically explore the bidirectional relationship between peripheral CD33 and AD. Genome-wide association study (GWAS) datasets of AD (N_cases: 21982; N_controls: 41944), blood CD33 mRNA level, the plasma CD33 protein level, and CD33 expression on immune-cell subtypes were obtained from GWASs conducted in the European population. Eligible IVs were extracted from the GWASs. MR estimates were calculated by inverse-variance weighting (IVW) and other sensitivity analyses. The main statistical analyses were conducted using Tw

SUBMITTER: Gu X 

PROVIDER: S-EPMC9529877 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature