Predicting response of micrometastases with MIRDcell V3: proof of principle with ²²⁵Ac-DOTA encapsulating liposomes that produce different activity distributions in tumor spheroids.

ABSTRACT:

Purpose

The spatial distribution of radiopharmaceuticals within multicellular clusters is known to have a significant effect on their biological response. Most therapeutic radiopharmaceuticals distribute nonuniformly in tissues which makes predicting responses of micrometastases challenging. The work presented here analyzes published temporally dependent nonuniform activity distributions within tumor spheroids treated with actinium-225-DOTA encapsulating liposomes (²²⁵Ac-liposomes) and uses these data in MIRDcell V3.11 to calculate absorbed dose distributions and predict biological response. The predicted responses are compared with experimental responses.

Methods

Four types of liposomes were prepared having membranes with different combinations of release (R) and

SUBMITTER: Katugampola S 

PROVIDER: S-EPMC9529908 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature