Serum level of IFNβ distinguishes early from late relapses after biologics withdrawal in rheumatoid arthritis.

ABSTRACT: Since the advent of biological disease modifying anti-rheumatic drugs (bDMARDs) in the treatment of rheumatoid arthritis (RA), most RA patients receiving such drugs have achieved remission at the expense of cost and infection risk. After bDMARDs are withdrawn, a substantial proportion of patients would have relapses even if they were in complete remission. In our previous report, relapse prediction could be made at the time of bDMARD withdrawal by measuring the serum levels of five cytokines. We report herein that, among 73 cytokines examined, serum levels of only interferon β (IFNβ) at the time of bDMARD withdrawal could predict early relapse (within 5 months) in patients who were categorized to relapse by the five cytokines in our previous report, with a cut-off value of 3.38 in log

SUBMITTER: Sakashita E 

PROVIDER: S-EPMC9529916 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature