Genome-wide association study of aromatase inhibitor discontinuation due to musculoskeletal symptoms.

ABSTRACT:

Objective

Aromatase inhibitors (AIs) are commonly used to treat hormone receptor positive (HR +) breast cancer. AI-induced musculoskeletal syndrome (AIMSS) is a common toxicity that causes AI treatment discontinuation. The objective of this genome-wide association study (GWAS) was to identify genetic variants associated with discontinuation of AI therapy due to AIMSS and attempt to replicate previously reported associations.

Methods

In the Exemestane and Letrozole Pharmacogenetics (ELPh) study, postmenopausal patients with HR + non-metastatic breast cancer were randomized to letrozole or exemestane. Genome-wide genotyping of germline DNA was conducted followed by imputation. Each imputed variant was tested for association with time-to-treatment discontinuation due to AIMSS u

SUBMITTER: Hertz DL 

PROVIDER: S-EPMC9529953 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature